Design of the study:
Blinded, randomized, prospective, 200 adults undergoing elective coronary artery bypass graft (CABG) procedure
 

Methods:
-Two groups, active treatment vs. control.
-Active: continuous bifrontal regional cerebral oxygen saturation (rSO2) N=100
-Alarm if 75% of baseline and management to keep rSO2 above 75% of baseline (increasing FiO2, initiating of pulsatile perfusion, 50-100 mg boluses of propofol, keeping hct >20%)
 

Results:
-More pts in the control group had prolonged desaturations (p=0.014)
-Control: more frequent major organ morbidity and mortality (p=0.07)
-Duration of postop ventilation and length of stay were similar
-ICU stay was longer for control (p=0.029)
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Conclusion/take home message:
-Treating rSO2 to keep >75% of baseline was associated with a shorter ICU stay and reduced incidence of MOMM in adults undergoing CABG